We’ve seen how major television networks such as Fox, NBC, CBS, and ABC and second-tier networks like The CW have been using the Web, but noticeably absent from this activity has been creative powerhouse HBO.

HBO on Monday announced it will be using the Web slightly differently than most, launching its own Web video series called “Hooking Up.” It’s a part of HBOlab, an experimental offshoot of the cable network’s online programming.

Jessica Rose of “lonelygirl15” will star in a 10-part show that begins airing on Oct. 1 on its own site — Hookingupshow.com — and on MySpaceTV and YouTube. Rose is accompanied on the show by video bloggers sxePhil and KevJumba, giving the program three of the Internet’s most popular entertainers.

“I think we’re going to see a lot more hits than had we cast a bunch of funny people you didn’t know,” said Fran Shea, head of HBOlab.